SARMS
The term SARMS stands for �Selective Androgen Receptor Modulators.� Androgens are a class of hormones that serve as ligands that bind to cellular androgen receptors. The androgen receptor is involved in a complex signal transduction pathway that ultimately results in greater expression of specific genes.
All anabolic steroids and pro hormones offer their muscle building properties through this binding to the androgen receptor.
A drug that can either block or stimulate the same nuclear hormone receptor under different conditions is called a selective receptor modulator. If it can block or stimulate a receptor in a tissue selective manner, it may be able to mimic the beneficial effects in one tissue and, at the same time, minimize the unwanted effects of the natural or synthetic steroidal hormones in other tissues.
SARMs
SARMS offer the benefits of traditional Anabolic Androgenic Steroids such as testosterone (including increased muscle mass, fat loss, and bone density), all the while, offering a much lower tendency to produce the unwanted side effects that come with steroids.
If you are able to stimulate a receptor in a tissue selective manner, (in our case, selective to bone and muscle) it is possible to mimic the beneficial effects of androgen activation in muscles, and at the same time, minimize the unwanted effects of the natural or synthetic steroidal hormones in other tissues.
It is this specificity that makes these receptor modulators able to selectively cause muscle growth, while reducing or eliminating unwanted secondary side effects.
How many SARMs are there?
There are hundreds of possible SARMS out there but there are two main SARMS currently available and most applicable to bodybuilders/fitness enthusiasts/athletes, with many user accounts, reviews and logs on the internet are Ostarine (MK-2866) and S-4 (Andarine).
How this applies to Body Builders
For the body builder/gym user/fitness enthusiast/athlete SARMs can be used either in conjunction with or as a replacement for traditional anabolics in the following uses:
� Lean muscle growth
� Preventing muscle loss during cutting/weight loss
� Injury rehabilitation
� PCT use after anabolics.
Of course the benefits when compared to steroids:
� Oral (no injections needed)
� Similar effects to testosterone (libido, strength gains, fat loss etc�)
� No conversion to Dihydrotestosterone
� No conversion to Estrogen
� No harsh liver toxicity from methylated compounds
� Does not inhibit your HPTA to the large extent of sterodis (no large reduction in LH or FSH)
� Legal
� Undetectable (select SARMs)